Vorlesung "Biomolecular NMR Spectroscopy"

Lecture Biomolecular NMR-Spectroscopy (2 SWS) CH3184a

Chemie (M.Sc.): Schwerpunkt "Biolog. Chemie" (Wahlpflicht, inkl. Praktikum!), alle HF/NF (Wahlveranstaltung);
Biochemie (M.Sc.): chem. NF
4 ECTS (only lecture) / 5 ECTS (incl. Practical)

Lecturer: Michael Sattler

Time:   Friday 10:15 h - 12:00 h; starting Fri Oct 20, 2023

Location: Lecture room CH 22209. The lecture will be given live. Handouts and further information will be provided in MOODLE.


Prüfung: Modulprüfung (oral exam after lecture or after practica, resp.)

Module: for the full module (5 ECTS) participation in the Practical Biomol. NMR (CH3184b, summer term) is also required!

 

Content:

Basic experiments and applications of biomolecular NMR-spectroscopy

  • Structure and conformation of proteins and nucleic acids
  • Basic NMR experiments and information provided
  • Structure determination and NMR of biological macromolecules (proteins, RNA) - AI/ML structure predictions
  • Ligand binding, drug discovery
  • Studying conformational dynamics by NMR
  • Current topics (dynamics, IDPs, large proteins, drug discovery, in cell NMR, PREs, AI/ML)