Lecture Biomolecular NMR-Spectroscopy  CH3184a. (Vorlesung 2 SWS)

Chemie (M.Sc.): Schwerpunkt "Biolog. Chemie" (Wahlpflicht, ink. Praktikum), alle HF/NF (Wahlveranstaltung);
Biochemie (M.Sc.): chem. NF

Lecturer: M. Sattler, G. Gemmecker

Time:   Friday 10:15 h - 12:00 h; starting Fri Oct. 25, 2019

Location:  CH 22209

Prüfung: Modulprüfung (oral exam after lecture or after practica, resp.)



Will be provided at MOODLE.



Basic experiments and applications of biomolecular NMR-spectroscopy

  • Structure of proteins and nucleic acids
  • Basic NMR experiments and information provided
  • Structure determination and NMR of biological macromolecules (proteins, RNA)
  • Ligand binding
  • Studying conformational dynamics by NMR
  • Current topics (dynamics, IDPs, in cell NMR, PREs)



Introduction, protein & nucleic acid structure [pdf]

Basics, Fourier transform, J-couplings, correlation experiments [pdf] final

NOE, structure determination of proteins [pdf]  final

Protein-ligand interactions; large proteins [pdf] final

Dynamics, internal motion, IDPs In cell  NMR, PREs [pdf]