Publications 2020

Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMO, Paissoni C, Bach A, Sattler M, Camilloni C
The dynamics of linear polyubiquitin.
(2020) Sci Adv 6. doi: 10.1126/sciadv.abc3786

Zaucha J, Softley CA, Sattler M, Frishman D, Popowicz GM
Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.
(2020) Chem Commun (Camb) 56, 15454-15457. doi: 10.1039/d0cc04383d

Calonaci N, Jones A, Cuturello F, Sattler M, Bussi G
Machine learning a model for RNA structure prediction.
(2020) NAR Genom Bioinform 2, lqaa090.   doi: 10.1093/nargab/lqaa090

Vieweg S, Mulholland K, Brauning B, Kachariya N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
(2020) Biochem J 477, 1651-1668. doi: 10.1042/BCJ20190664

Su W, Tan H, Janowski R, Zhang W, Wang P, Zhang J, Zhai H, Li J, Niessing D, Sattler M, Zou P
Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.
(2020) Mol Pharm 17, 1663-1673. doi: 10.1021/acs.molpharmaceut.0c00098

Soni K, Martinez-Lumbreras S, Sattler M
Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.
(2020) J Mol Biol 432, 4127-4138. doi: 10.1016/j.jmb.2020.05.012

Solbak SMO, Zang J, Narayanan D, Hoj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
(2020) J Med Chem 63, 1156-1177. doi: 10.1021/acs.jmedchem.9b01492

Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM
Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
(2020) Antimicrob Agents Chemother 64. doi: 10.1128/AAC.00123-20

Softley CA, Bostock MJ, Popowicz GM, Sattler M
Paramagnetic NMR in drug discovery.
(2020) J Biomol NMR 74, 287-309. doi: 10.1007/s10858-020-00322-0

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchene J, Megens RTA, Sattler M, Weber C
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
(2020) Sci Transl Med 12. doi: 10.1126/scitranslmed.aaz2294

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchene J, Megens RTA, Sattler M, Weber C
Autophagy unleashes noncanonical microRNA functions.
(2020) Autophagy 16, 2294-2296. doi: 10.1080/15548627.2020.1830523

Reinking HK, Kang HS, Gotz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
(2020) Mol Cell 80, 102-113 e6. doi: 10.1016/j.molcel.2020.08.003

Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
(2020) Chem Commun (Camb) 56, 4360-4363. doi: 10.1039/c9cc07714f

Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.
(2020) Angew Chem Int Ed Engl 59, 5771-5781. doi: 10.1002/anie.201914559

Mader SL, Lopez A, Lawatscheck J, Luo Q, Rutz DA, Gamiz-Hernandez AP, Sattler M, Buchner J, Kaila VRI
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.
(2020) Nat Commun 11, 1410. doi: 10.1038/s41467-020-15050-0

Kang HS, Sanchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, Konig J, Sattler M
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
(2020) Proc Natl Acad Sci U S A 117, 7140-7149. doi: 10.1073/pnas.1913483117

Jagtap PKA, Kubelka T, Soni K, Will CL, Garg D, Sippel C, Kapp TG, Potukuchi HK, Schorpp K, Hadian K, Kessler H, Luhrmann R, Hausch F, Bach T, Sattler M
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
(2020) Nat Commun 11, 5621. doi: 10.1038/s41467-020-19514-1

Gottlicher M, Sattler M, Bronstrup M
New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC).
(2020) ChemMedChem 15, 468-470. doi: 10.1002/cmdc.202000019

Fino R, Byrne R, Softley CA, Sattler M, Schneider G, Popowicz GM
Introducing the CSP Analyzer: A novel Machine Learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening.
(2020) Comput Struct Biotechnol J 18, 603-611. doi: 10.1016/j.csbj.2020.02.015

Donau C, Spath F, Sosson M, Kriebisch BAK, Schnitter F, Tena-Solsona M, Kang HS, Salibi E, Sattler M, Mutschler H, Boekhoven J
Active coacervate droplets as a model for membraneless organelles and protocells.
(2020) Nat Commun 11, 5167. doi: 10.1038/s41467-020-18815-9

Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C
The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins.
(2020) Chemphyschem 21, 863-869. doi: 10.1002/cphc.202000071

Delhommel F, Sattler M
When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.
(2020) Structure 28, 730-732. doi: 10.1016/j.str.2020.06.005

Delhommel F, Gabel F, Sattler M
Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes.
(2020) J Mol Biol 432, 2890-2912. doi: 10.1016/j.jmb.2020.03.014

De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT
Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.
(2020) Neurochem Int 136, 104713. doi: 10.1016/j.neuint.2020.104713

Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Maser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM
Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
(2020) J Med Chem 63, 847-879. doi: 10.1021/acs.jmedchem.9b01876

Barthelmes K, Ramcke E, Kang HS, Sattler M, Itzen A
Conformational control of small GTPases by AMPylation.
(2020) Proc Natl Acad Sci U S A 117, 5772-5781. doi: 10.1073/pnas.1917549117