Vorlesung "Biomolecular NMR Spectroscopy"

Lecture Biomolecular NMR-Spectroscopy

Vorlesung, 2 SWS; Chemie (M.Sc.): NF Biolog. Chemie (Pflichtveranst. mit Praktikum), alle HF/NF (Wahlpflicht); Biochemie (M.Sc.): chem. NF

Lecturer: M. Sattler, G. Gemmecker

Time:   Friday 10:15 h - 12:00 h; starting Fri Oct. 20, 2016

Location:  CH 22209

Prüfung: Modulprüfung (oral exam after lecture or after practica, resp.)

 

Handouts

Will be provided at MOODLE.

 

Content:

Basic experiments and applications of biomolecular NMR-spectroscopy

  • Structure of proteins and nucleic acids
  • Basic NMR experiments and information provided
  • Structure determination and NMR of biological macromolecules (proteins, RNA)
  • Ligand binding
  • Studying conformational dynamics by NMR
  • Current topics (dynamics, IDPs, in cell NMR, PREs)

 

OLD:

Introduction, protein & nucleic acid structure [pdf]

Basics, Fourier transform, J-couplings, correlation experiments [pdf] final

NOE, structure determination of proteins [pdf]  final

Protein-ligand interactions; large proteins [pdf] final

Dynamics, internal motion, IDPs In cell  NMR, PREs [pdf]