Publications 2021

Zhang X, Schuhmachers P, Mourao A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck S, Hammerschmidt W, Kuppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Munz C, Kempkes B.
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
(2021) Embo Reports 22.   doi: 10.15252/embr.202153007

Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P.
Albumin-binding domain extends half-life of glucagon-like peptide-1.
(2021) European Journal of Pharmacology 890.   doi: 10.1016/j.ejphar.2020.173650

Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P.
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
(2021) International Journal of Pharmaceutics 607.   doi: 10.1016/j.ijpharm.2021.121043

Stadler D, Kachele M, Jones A, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou W, Geerlof A, van de Klundert M, Wettengel J, Schirmacher P, Heikenwalder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U.
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
(2021) Embo Reports 22.   doi: 10.15252/embr.201949568

Schuch L, Forstner M, Rapp C, Li Y, Smith D, Mendes M, Delhommel F, Sattler M, Emiralioglu N, Taskiran E, Orhan D, Kiper N, Rohlfs M, Jeske T, Hastreiter M, Gerstlauer M, Torrent-Vernetta A, Moreno-Galdo A, Kammer B, Brasch F, Reu-Hofer S, Griese M.
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!
(2021) Clinical Genetics 99, 789-801.   doi: 10.1111/cge.13943

Savitskiy S, Wachtel R, Pourjafar-Dehkordi D, Kang H, Trauschke V, Lamb D, Sattler M, Zacharias M, Itzen A.
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.
(2021) Iscience 24.   doi: 10.1016/j.isci.2020.101940

Romero A, Lunev S, Popowicz G, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak T, Domling A, Groves M.
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
(2021) Communications Biology 4.   doi: 10.1038/s42003-021-02442-1

Reuter M, Kooshapur H, Suda J, Gaussmann S, Neuhaus A, Bruhl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R.
Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
(2021) Journal of Molecular Biology 433.   doi: 10.1016/j.jmb.2020.166765

Pallesen J, Narayanan D, Tran K, Solbak S, Marseglia G, Sorensen L, Hoj L, Munafo F, Carmona R, Garcia A, Desu H, Brambilla R, Johansen T, Popowicz G, Sattler M, Gajhede M, Bach A.
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
(2021) Journal of Medicinal Chemistry 64, 4623-4661.   doi: 10.1021/acs.jmedchem.0c02094

Munshaw S, Bruche S, Redpath A, Jones A, Patel J, Dube K, Lee R, Hester S, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon K, Smart N.
Thymosin beta 4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
(2021) Journal of Clinical Investigation 131.   doi: 10.1172/JCI127884

Lopez A, Elimelech A, Klimm K, Sattler M.
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90.
(2021) Chembiochem 22, 1084-1092.   doi: 10.1002/cbic.202000699

Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M.
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
(2021) Science Advances 7.   doi: 10.1126/sciadv.abl7295

Liwocha J, Krist D, van Noort G, Hansen F, Truong V, Karayel O, Purser N, Houston D, Burton N, Bostock M, Sattler M, Mann M, Harrison J, Kleiger G, Ovaa H, Schulman B.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
(2021) Nature Chemical Biology 17, 272-+.   doi: 10.1038/s41589-020-00696-0

Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V, Kim C, Laufer J, Zemp R.
Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.
(2021) Opto-Acoustic Methods and Applications in Biophotonics V 11923.   doi: 10.1117/12.2615998

Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V.
Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
(2021) Advanced Healthcare Materials 10.   doi: 10.1002/adhm.202002115

Liu N, Gujrati V, Malekzadeh-Najafabadi J, Werner J, Klemm U, Tang L, Chen Z, Prakash J, Huang Y, Stiel A, Mettenleiter G, Aichler M, Blutke A, Walch A, Kleigrewe K, Razansky D, Sattler M, Ntziachristos V.
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
(2021) Photoacoustics 22.   doi: 10.1016/j.pacs.2021.100263

Li M, Gaussmann S, Tippler B, Ott J, Popowicz G, Schliebs W, Sattler M, Erdmann R, Kalel V.
Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
(2021) Frontiers in Cell and Developmental Biology 9.   doi: 10.3389/fcell.2021.737159

Georgiadi A, Lopez-Salazar V, El-Merahbi R, Karikari R, Ma X, Mouraeo A, Klepac K, Buehler L, Alfaro A, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Mueller T, Kessler K, Schoeneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer A, Sattler M, Blueher M, Herzig S.
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
(2021) Nature Communications 12.   doi: 10.1038/s41467-021-22579-1

Gaussmann S, Gopalswamy M, Eberhardt M, Reuter M, Zou P, Schliebs W, Erdmann R, Sattler M.
Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14.
(2021) Frontiers in Cell and Developmental Biology 9.   doi: 10.3389/fcell.2021.651449

Fukumura K, Yoshimoto R, Sperotto L, Kang H, Hirose T, Inoue K, Sattler M, Mayeda A.
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
(2021) Nature Communications 12.   doi: 10.1038/s41467-021-24879-y

Fottner M, Weyh M, Gaussmann S, Schwarz D, Sattler M, Lang K.
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.
(2021) Nature Communications 12.   doi: 10.1038/s41467-021-26812-9

Fino R, Lenhart D, Kalel V, Softley C, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz G.
Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
(2021) Journal of Chemical Information and Modeling 61, 5256-5268.   doi: 10.1021/acs.jcim.1c00472

de Souza Degenhardt MF, Vitale PAM, Abiko LA, Zacharias M, Sattler M, Oliveira CLP, Salinas RK.
Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS.
(2021) Biophys J 120, 3664-3675.   doi: 10.1016/j.bpj.2021.07.022

Biebl M, Lopez A, Rehn A, Freiburger L, Lawatscheck J, Blank B, Sattler M, Buchner J.
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
(2021) Nature Communications 12.   doi: 10.1038/s41467-021-21063-0