Publications 2020

Vieweg S, Mulholland K, Brauning B, Kachariya N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
(2020) Biochem J 477, 1651-1668.   doi: 10.1042/bcj20190664

Su WC, Tan HB, Janowski R, Zhang WY, Wang PJ, Zhang J, Zhai HH, Li J, Niessing D, Sattler M, Zou PJ
Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.
(2020) Mol Pharm 17, 1663-1673.   doi: 10.1021/acs.molpharmaceut.0c00098

Soni K, Martinez-Lumbreras S, Sattler M
Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.
(2020) J Mol Biol 432, 4127-4138.   doi: 10.1016/j.jmb.2020.05.012

Solbak SMO, Zang J, Narayanan D, Hoj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
(2020) J Med Chem 63, 1156-1177.   doi: 10.1021/acs.jmedchem.9b01492

Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM
Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
(2020) Antimicrobial Agents and Chemotherapy 64.   doi: 10.1128/aac.00123-20

Softley CA, Bostock MJ, Popowicz GM, Sattler M
Paramagnetic NMR in drug discovery.
(2020) J Biomol NMR 74, 287-309.   doi: 10.1007/s10858-020-00322-0

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourao A, Blanchet X, Wichapong K, Aslani M, Brunssen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen M, Hackeng TM, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchene J, Megens RTA, Sattler M, Weber
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
(2020) Science Translational Medicine 12.   doi: 10.1126/scitranslmed.aaz2294

Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Satter M, Popowicz G, Tetko IV
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
(2020) Chemical Communications 56, 4360-4363.   doi: 10.1039/c9cc07714f

Mader SL, Lopez A, Lawatscheck J, Luo Q, Rutz DA, Gamiz-Hernandez AP, Sattler M, Buchner J, Kaila VRI
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.
(2020) Nat Commun 11.   doi: 10.1038/s41467-020-15050-0

Kang HS, Sanchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, Konig J, Sattler M
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
(2020) Proc Natl Acad Sci USA 117, 7140-7149.   doi: 10.1073/pnas.1913483117

Gottlicher M, Sattler M, Bronstrup M
New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC).
(2020) Chemmedchem 15, 468-470.   doi: 10.1002/cmdc.202000019

Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C
The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins.
(2020) Chemphyschem 21, 863-869.   doi: 10.1002/cphc.202000071

Delhommel F, Gabel F, Sattler M
Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes.
(2020) J Mol Biol 432, 2890-2912.   doi: 10.1016/j.jmb.2020.03.014

De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT
Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.
(2020) Neurochem Int 136.   doi: 10.1016/j.neuint.2020.104713

Barthelmes K, Ramcke E, Kang HS, Sattler M, Itzen A
Conformational control of small GTPases by AMPylation.
(2020) Proc Natl Acad Sci USA 117, 5772-5781.   doi: 10.1073/pnas.1917549117

Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.
(2020) Angew Chem Int Ed Engl 59, 5771-5781.   doi: 10.1002/anie.201914559

Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Maser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM
Structure-Activity Relationship in Pyrazolo 4,3-c pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
(2020) J Med Chem 63, 847-879.   doi: 10.1021/acs.jmedchem.9b01876